Posters & Publications

Bonfils C. et al., AACR 2012 Annual Meeting, April 2012The Combination of MGCD265, a Met/VEGFR Inhibitor in Clinical Development, and Erlotinib Potently Inhibits Tumor Growth by Altering Multiple Pathways Including GlycolysisLien download
Wheler, J. et al. AACR-NCI-EORTC 2011, November 2011The Determination of the Maximum Tolerated Dose (MTD) of MGCD265 on an Intermittent Schedule: Phase I Study Results (Study 265-102)Lien download
Rasco, D. W., et al. ASCO 2011 Annual Meeting, June 2011Determination of the maximum tolerated dose (MTD) of MGCD265, an oral Met/VEGFR multi-targeted receptor tyrosine kinase inhibitor, in combination with docetaxelLien download
O’Dwyer, Peter et al. ASCO 2011 Annual Meeting, June 2011MGCD265, an oral Met/VEGFR multi-targeted receptor tyrosine kinase inhibitor, in combination with erlotinib: Phase 1 clinical experienceLien download
Bonfils, C. et al. AACR 102nd Annual Meeting, April 2011Potent preclinical anti-tumor activity of MGCD265, an oral Met/VEGFR multi-targeted kinase inhibitor in clinical development, in combination with taxanesLien download
Patnaik, A. et al. 22nd EORTC-NCI-AACR, November 2010MGCD265, an orally active Met/VEGFR multi-targeted kinase inhibitor, in combination with erlotinib : clinical and preclinical experienceLien download
O’Dwyer, P. et al. 22nd EORTC-NCI-AACR, November 2010MGCD265, an orally active Met/VEGFR multi-targeted kinase inhibitor, in combination with docetaxel : clinical and preclinical experienceLien download
Heath, E. et al., 2010 ASCO Annual Meeting, June 2010A phase I study of oral administration of MGCD265 in patients with advanced malignancies (study 265-102)Lien download
Drouin, M. et al., 2010 ASCO Annual Meeting, June 2010Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study (265-101)Lien download
Besterman, J. et al., 2010 ASCO Annual Meeting, June 2010Potent preclinical anti-tumor activity of MGCD265, an oral Met/VEGFR kinase inhibitor in phase II clinical development, in combination with taxanes or erlotinibLien download
Fournel, M. Et al., 2010 AACR Annual Meeting, April 2010Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multi-targeted kinase inhibitors in phase Ii clinical development, in combination with an EGFR inhibitorLien download
Beaulieu, N. et al. 2010 AACR 101st Annual Meeting, April 2010MGCD265, an orally active Met/VEGFR multi-targeted kinase inhibitor in Phase II clinical development, potently inhibits clinically relevant Met mutantsLien download
LoRusso, P. et al., 2009 AACR-NCI-EORTC International Conference, November 2009A phase I dose-escalation study of MGCD265 in patients with advanced malignancies (study 265-102)Lien download
Kollmannsberger, C.K. et al. 2009 ASCO Annual Meeting, May 2009Phase I study of daily administration of MGCD265 to patients with advanced malignancies (Study 265-101)Lien download
Hong, D. et al. 2009 ASCO Annual Meeting, May 2009Phase I study of MGCD265 administered intermittently to patient s with advanced malignancies (Study 265-102)Lien download
Beaulieu, N. et al. 20th EORTC-NCI-AACR Symposium, October 2008Preclinical pharmacodynamic markers of MGCD265, a potent orally active c-Met/VEGFR multi-targeted kinase inhibitor in phase I clinical trialsLien download
Besterman, J. 3rd Protein Kinases in Drug Discovery Conference, May 2008MGCD265, a multi-targeted kinase inhibitorLien download
Beaulieu, N. et al. AACR Annual Meeting 2008, April 2008Preclinical development of MGCD265, a potent orally active c-Met/VEGFR multi-target kinase inhibitorLien download
Saavedra, O. et al., Gordon Research Conference, August 2007A new series of Thieno[3,2-b] pyridines, inhibitors of the HGF and VEGF receptor familyLien download
Raeppel, S. et al., 43rd International Conference on Medicinal Chemistry, July 2007Inhibitors targeting multiple receptor tyrosine kinases for anticancer therapiesLien download
Vaisburg, A. CHI's 5th Annual Protein Kinase Targets Conference, June 2007Thienopyridine-Based Multi-Targeted Kinase Inhibitors Lien download
Beaulieu, N., et al. 18th EORTC-NCI-AACR Cancer Symposium, Nov. 7-10, 2006, PragueIdentification and characterization of novel, orally active inhibitors of c-MET and Ron Receptor Tyrosine KinasesLien download
Claridge, S. et al., 232nd ACS National Meeting, Sept 10-14, 2006, San FranciscoNoel Thieno[3,2-b]pyridine Scaffold Based Inhibitors of the c-Met and VEGFR Receptor FamilyLien download
Nguyen, H. et al, AACR 9th Annual Meeting, April 1-5, 2006, Washington DCEvaluation of Antitumor Activity, Anti-Angiogenic Activity and Pharmacodynamic End Points for Orally Active Multi-Targeted Anti-Angiogenic Kinase Inhibitors Targeting c-MET, Ron, VEGF and Tie-2 ReceptorsLien download
Beaulieu, N. et al, ACCR-NCI-EORTC, November 14-18, 2005, PhiladelphiaNovel, Orally Active Multi-Kinase Inhibitors of c-MET and the VEGF Receptor Family Exhibit Potent Antiangiogenic Activity and Antitumour Efficacy in Preclinical ModelsLien download